For the quarter ended June 2024, Alnylam Pharmaceuticals (ALNY Quick QuoteALNY - Free Report) reported revenue of $659.83 million, up 107% over the same period last year. EPS came in at $0.56, compared to -$2.21 in the year-ago quarter.

The reported revenue compares to the Zacks Consensus Estimate of $448.44 million, representing a surprise of +47.14%. The company delivered an EPS surprise of +175.68%, with the consensus EPS estimate being -$0.74.

While investors closely watch year-over-year changes in headline numbers -- revenue and earnings -- and how they compare to Wall Street expectations to determine their next course of action, some key metrics always provide a better insight into a company's underlying performance.

As these metrics influence top- and bottom-line performance, comparing them to the year-ago numbers and what analysts estimated helps investors project a stock's price performance more accurately.

Here is how Alnylam performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:

• Net Product Revenue- Oxlumo- United States

  : $15.74 million compared to the $12.79 million average estimate based on two analysts.

• Net Product Revenue- Amvuttra- United States

  : $148.46 million versus the two-analyst average estimate of $134.14 million. The reported number represents a year-over-year change of +53.9%.

• Net Product Revenue- Givlaari- United States

  : $41.23 million versus the two-analyst average estimate of $38.70 million. The reported number represents a year-over-year change of +17.1%.

• Net Product Revenue- Onpattro- United States

  : $22.11 million compared to the $12.91 million average estimate based on two analysts. The reported number represents a change of -13.5% year over year.

• Product revenues, net

  : $410.09 million versus $364.77 million estimated by 10 analysts on average. Compared to the year-ago quarter, this number represents a +34.2% change.

• Royalty revenue

  : $22.40 million versus $16 million estimated by nine analysts on average. Compared to the year-ago quarter, this number represents a +210.9% change.

• Net revenues from research collaborators

  : $227.34 million versus the nine-analyst average estimate of $69.50 million. The reported number represents a year-over-year change of +3790.1%.

• Net Product Revenues- Givlaari

  : $62.13 million versus $61.43 million estimated by seven analysts on average. Compared to the year-ago quarter, this number represents a +7.3% change.

• Net Product Revenue- Oxlumo

  : $40.61 million versus $36.55 million estimated by seven analysts on average. Compared to the year-ago quarter, this number represents a +67.7% change.

• Net Product Revenue- Amvuttra

  : $230.11 million versus the six-analyst average estimate of $205.18 million. The reported number represents a year-over-year change of +74.2%.

• Net Product Revenues- Onpattro

  : $77.24 million versus the six-analyst average estimate of $57.69 million. The reported number represents a year-over-year change of -15.5%.

• Net revenues from research collaborators- Novartis AG

  : $2.30 million versus $14.84 million estimated by three analysts on average.

View all Key Company Metrics for Alnylam here>>>

Shares of Alnylam have returned -4.5% over the past month versus the Zacks S&P 500 composite's +1.1% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.